About this ingredient
Ingredients
Serrapeptase, also known as serratiopeptidase, is a proteolytic enzyme originally identified in the bacterium Serratia species associated with the silkworm. It is used in some dietary supplements and enzyme formulations. The exact enzyme activity, potency, source, enteric coating, serving size, and additional ingredients vary by manufacturer.
Serrapeptase (Serratiopeptidase) is a proteolytic, or protein-digesting, enzyme that has been studied for its potential effects on inflammation, swelling, and recovery following certain procedures. It is available in some enzyme-based dietary supplements and formulations.
Research has investigated serrapeptase in several clinical settings, including postoperative swelling and discomfort. Some individual studies have reported potential benefits, but systematic reviews have noted limitations such as small study sizes, variable methodology, and insufficient long-term safety data. Therefore, evidence is not strong enough to establish broad therapeutic benefits.
Serrapeptase supplements may be supplied as capsules or tablets, with some products using enteric-coated formulations intended to protect the enzyme from stomach conditions. Enzyme activity may be expressed in activity units rather than simply by weight, making the product's stated potency important when comparing formulations.
Because safety and drug-interaction information is not fully established, people taking medicines, preparing for surgery, pregnant or breastfeeding individuals, or those with medical conditions should consult a qualified healthcare professional before using serrapeptase. General supplement guidance also recommends considering potential medication interactions and product quality.